|A high protein, high fat, and reduced carbohydrate
diet is preferred when a person starts Prokarin. This
is often confusing to patients because many of them have been
using a low fat diet and it has been beneficial in slowing the
progression of their symptoms. Dr. Swank had found that his
patients were unable to metabolize fats, so he recommended a
low fat diet to avoid an increased stress on the body from a
build up of unmetabolized fats.
The reason the Dr. Swank low fat diet showed
benefit maybe because a deficiency in histamine impairs fat
and protein digestion and fat metabolism. Histamine stimulates
the production of gastric acid and digestive enzymes, which
are necessary for protein and fat digestion (Baer & Williams,
1992). The inadequate secretion of gastric acid and digestive
enzymes due to a histamine deficiency results in the body
becoming more dependent on carbohydrates for its energy. Thus,
high total cholesterol may be common in histamine deficient
patients because the body makes cholesterol from carbohydrates.
Furthermore, the majority of cholesterol is made in the cell
membranes, which acts as a stiffening agent used to balance
the ratio of unsaturated to saturated fats in the cell membranes
(Erasmus, 1986). Interestingly, a study by Mensink et al in
1992 showed that the medial level of serum lipoprotein[a]
was lower in a saturated fat diet than in a cis-unsaturated
or trans-unsaturated fat diet. An impaired fat metabolism
due to a histamine deficiency may add to a high cholesterol
Histamine stimulates the production of melatonin
by stimulating the activity of the pineal gland (Nowak &
Sek, 1994). Melatonin is essential in fat metabolism as the
pineal gland is the only area in the brain that can metabolize
polyunsaturated fats by lipid oxygenation, whereas all other
areas of the brain can only metabolize these fats via lipid
peroxidation (Kim et al, 1999; Sawazaki et al, 1994). The
impaired fat metabolism resulting from a deficiency of melatonin
caused by a histamine deficiency may result in stress on the
body. This stress increases the need for histamine because
histamine is a major stress regulator for the body (Ghi et
al, 1992). The increased demand for histamine contributes
to a worsening/progression of symptoms if the person is already
deficient in histamine.
Supplementing histamine through the administration
of Prokarin can increase melatonin secretion as well
as increase gastric acid and digestive enzyme production,
which enhances fat and protein digestion and fat metabolism.
Increased fat metabolism requires adequate fat intake to replenish
the necessary fats. If the fat intake is inadequate, a person
can experience severe weakness as well as neurological symptoms
since the majority of the myelin and nervous system is composed
of fats called phospholipids. It is imperative that the dietary
fat intake is a balance of saturated and unsaturated fats.
Research studies show that diets high in unsaturated fats
and low in saturated fats result in increased lipid peroxidation.
Lipid peroxidation is toxic to the cell membranes. The myelin
and nerve cell membranes are very vulnerable to the cytotoxic
effects of lipid peroxidation (Smith et al, 1999; Mazierre
et al, 1999; Berry et al, 1991; de Kok et al, 1994; Fang et
al, 1996; Fernstrom 1999).
Most of the medical community is aware of the
increased risk of cancer. Oxidation of the double bonds in
unsaturated fats results in an increase in free radicals,
so antioxidant supplements are recommended when supplementing
unsaturated essential fatty acids, such as Omega-3 and 6,
flaxseed oil, primrose oil, borage oil, and fish oils. The
problem with this according to studies, such as Alam et al
in 1989 and Syburra &Passi in 1999, is that unsaturated
dietary fat can lower the level of beta-carotene and other
antioxidants including enzymatic ones circulating in the plasma.
It has been shown in research by Bougnoux 1999
& Maehle et al 1999, that the unsaturated fats particularly
omega 3 are cytotoxic to tumor cells because of their lipid
peroxidation properties. Unfortunately the cytotoxicity of
the unsaturated fat is not selective so all cells, cancerous
and healthy, can be destroyed by the lipid peroxidation. In
fact research by Smith et al 1999, explains that oligodendrocytes
(the myelin producing cells of the CNS) are more sensitive
to oxidative stress from lipid peroxidation than other cells
of the nervous system. Thus lipid peroxidation can result
in selective oligodendrocyte death.
The risk of cancer from the effects of lipid
peroxidation from unsaturated fat metabolism is further increased
by the immunosuppressive effect of unsaturated fats. Unsaturated
fats exhibit an anti-inflammatory effect. Inflammation is
an integral part of the immune response. Studies show that
the N-3 unsaturated fatty acid exhibits a suppressive effect
on the cytokines of the immune system IL-1, IL-2, IL-6,
IL-10, IL-12, TNF-alpha, PGE2, TXB2, and LTB4. These serum
levels of these cytokines were further reduced by Vitamin
E supplementation used in conjunction with N-3 fatty acid
(Venkatraman & Chu, 1999; Meydani et al, 1991). Furthermore
the study by Meydani et al 1991 showed long term (N-3) fatty
acid supplementation reduced lymphocyte proliferation in older
women (51-68 yr). Thus the combined effect of lipid peroxidation
and immune suppression exerted by unsaturated fats could be
detrimental to ones health. Any patients who have a
suppressed immune system and / or a demyelinating disease
are possibly more prone to the detrimental effects of a diet
high in unsaturated fats.
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